It's possible, but it slows the simulation down by about 20fps just making it non-static.
This mod has allowed me to test the limits of my solar bomb. And man, it's an impressive size when its not limited by borders
http://i.imgur.com/SmcxyKT.png
I'm running a 2.6GHz quad-core CPU which is relatively decent. I also have 8GB RAM and a 2GB GTX550Ti so it just goes to show how intensive TPT is