Yeah i'm on Mac, at first it complains with /usr/include but i solve it with the instructions of the wiki, then it complains again about luajit though i installed it through Homebrew: 

The Meson build system

Version: 1.2.0

Source dir: /Users/masterkebabsuperstar/The-Powder-Toy

Build dir: /Users/masterkebabsuperstar/The-Powder-Toy/build-debug

Build type: native build

meson.build:1:0: ERROR: Unknown options: "PKG_CONFIG_PATH"

A full log can be found at /Users/masterkebabsuperstar/The-Powder-Toy/build-debug/meson-logs/meson-log.txt

masterkebabsuperstar@CreepCreepGoToURSheep The-Powder-Toy % meson setup -Dworkaround_elusive_bzip2=true -Dworkaround_elusive_bzip2_lib_dir=/opt/homebrew/Cellar/bzip2/1.0.8/lib -Dworkaround_elusive_bzip2_include_dir=/opt/homebrew/Cellar/bzip2/1.0.8/include -Dworkaround_elusive_bzip2_static=true  build-debug 

The Meson build system

Version: 1.2.0

Source dir: /Users/masterkebabsuperstar/The-Powder-Toy

Build dir: /Users/masterkebabsuperstar/The-Powder-Toy/build-debug

Build type: native build

Project name: the-powder-toy

Project version: the.cake.is.a.lie

C compiler for the host machine: cc (clang 13.0.0 "Apple clang version 13.0.0 (clang-1300.0.29.30)")

C linker for the host machine: cc ld64 711

C++ compiler for the host machine: c++ (clang 13.0.0 "Apple clang version 13.0.0 (clang-1300.0.29.30)")

C++ linker for the host machine: c++ ld64 711

Host machine cpu family: aarch64

Host machine cpu: aarch64

Program inkscape skipped: feature render_icons_with_inkscape disabled

Has header "bzlib.h" : YES 

Library bz2 found: YES

Found pkg-config: /opt/local/bin/pkg-config (0.29.2)

Found CMake: /opt/homebrew/bin/cmake (3.22.2)

Run-time dependency luajit found: NO (tried pkgconfig, framework and cmake)

meson.build:160:11: ERROR: Dependency "luajit" not found, tried pkgconfig, framework and cmake

Though i've been Googling like +2 hours, nothing to find about it that works well on Mac M1